Natural History Studies

Have you or a loved one been diagnosed with LBSL? Researchers would like to assess your clinical symptoms in order to expand knowledge of this disorder in the medical community. They hope this research can clarify the common and clinically important symptoms that should be targeted for new treatments.  For more information about participating in an LBSL natural history study, please click here.

United States​

Baltimore, Maryland​: Kennedy Krieger Institute / Johns Hopkins Medicine
Principal Investigators: Dr. Ali Fatemi and Dr. Amena Smith Fine
Contact: Amena Smith Fine, finea@kennedykrieger.org
Study Listing: ClinicalTrials.gov

Netherlands​

Amsterdam​: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)​
Principal Investigators: Dr. Marc Engelen
Contact: Marije Voermans, RN, 0205668227, m.m.voermans@amsterdamumc.nl
Study Listing: ClinicalTrials.gov

Finland​

Helsinki​, University of Helsinki
Principal Investigator: Dr. Emil Ylikallio​
Contact: emil.ylikallio@helsinki.fi 

Brazil​

Curitiba - State of Paraná, Brazil​, Hospital Pequeno Príncipe​
Principal Investigators: Dra. Josiane de Souza​
Contact: josiane.souza@hpp.gov.br

Convido para participar de uma pesquisa entitulada "Caracterização da história natural da leucoencefalopatia com acometimento de tronco encefálico e medula espinal e elevação de lactato".​ O participante deve ter diagnóstico de LBSL e análise molecular com alteração no gene DARS2.​ Para os interessados basta clicar no link a seguir e preencher o formulário de pré-inscrição: https://docs.google.com/forms/d/e/1FAIpQLSfu9_PTfFflr9P_WYcrjqhIAvsK9ajU0LrRATp0iQjJ842p8Q/viewform?usp=sharing
Essa pesquisa foi aprovada pelo Comitê de Ética em Pesquisa do Hospital Pequeno Príncipe: CAEE- 67371123.8.0000.0097​
Caso tenha dúvidas entrar em contato com: pibiclbsl@gmail.com

Primary US Site

Kennedy Krieger Institute / Johns Hopkins Medicine (Maryland, USA)​
Investigators: Dr. Ali Fatemi​ and Dr. Amena Smith Fine

International Sites

Amsterdam University Medical Center (Netherlands)​
Investigator: Dr. Marc Engelen

​University of Helsinki (Finland)​
Investigator: Dr. Emil Ylikallio

Eligibility

  • Do you or your child have a diagnosis of LBSL?

  • Is this diagnosis based on genetic testing?

  • Do you have regular access to the Internet?

If yes, then you may be eligible to participate in this study!

Contact

Dr. S Ali Fatemi - Principal Investigator
+1.443-923-2769
+1.443-923-1820
FineA@kennedykrieger.org